Peptide

Reference library

Educational peptide reference — research use only.

Research & educational use only

For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.

The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.

CognitivePeptideCognitive / neuro cluster

Snap-8

A synthetic octapeptide studied in neuromuscular and cosmetic research.

Half-life (approx.): Topical — local; injectable short (approx.)
Diluent: Bacteriostatic water (0.9% benzyl alcohol)
Common vials: 10, 20 mg

Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.

Overview

Snap-8 (acetyl octapeptide-3) is a botulinum-toxin-mimetic peptide studied for SNARE-complex modulation in cosmetic and neuromuscular research. Topical formulations dominate the literature, though injectable research exists at defined concentrations. SNARE-complex competitive inhibitor studied topically for wrinkle-depth reduction.

Structure & identity

Acetyl-Glu-Met-Gln-Arg-Pro-Arg-Pro octapeptide

Sequence / structure: Acetyl-Glu-Met-Gln-Arg-Pro-Arg-Pro octapeptide

Mechanism

Competitive SNARE complex inhibitor reducing muscle contraction signals — botulinum-mimetic. Botulinum-mimetic mechanism reduces neuromuscular signaling without toxin immunogenicity.

Studies & clinical programs

SNAP-25 competition assays
Published research models
- Peer-reviewed literature documents endpoints under SNAP-25 competition assays experimental designs.
Topical wrinkle depth measurement
Published research models
- Peer-reviewed literature documents endpoints under Topical wrinkle depth measurement experimental designs.

Research models in literature

SNAP-25 competition assays
Topical wrinkle depth measurement

Literature highlights

SNARE complex competitive inhibitor reduces muscle contraction signaling in wrinkle-depth studies.
Botulinum-mimetic mechanism studied topically and in injectable research formulations.
SNAP-25 binding assays used as primary mechanistic readout.

Combination research notes

Cosmetic peptide research lists SNAP-8 with GHK-Cu and copper tripeptides.

Key targets & pathways

SNAP-25SNARE complexSNAP-25 cleavage mimicryFacial muscle contraction

Research areas

SNARE complexCosmetic neuromodulationExpression lines

Routes in research literature

TopicalSubcutaneous

Also known as

Acetyl Octapeptide-3Snap 8

Stability & storage phases

Phase	Condition	Guidance
Lyophilized	Sealed vial, refrigerated (2–8 °C)	Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial.
Reconstituted	Bacteriostatic water (0.9% benzyl alcohol), refrigerated	Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date.
Working aliquots	Pre-drawn syringes or microtubes, frozen (−20 °C)	Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation.

Stability windows are formulation-dependent — verify published data and your lab SOP.

Reconstitution reference table

Vial (mg)	Diluent (mL)	mcg/mL	Units @ 100 mcg	Units @ 250 mcg	Units @ 500 mcg
10	2	5000.0	2	5	10
20	2	10000.0	1	2.5	5

U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.

Reconstitution steps

Allow vial to reach room temperature (15–30 min)
Swab rubber stopper with alcohol prep pad
Draw calculated bacteriostatic water into syringe
Inject diluent slowly down vial wall — do not spray directly onto cake
Gently swirl until fully dissolved — do not shake vigorously
Label with date, concentration, and diluent volume
Refrigerate and use within your lab stability window

Often used topically in research; injectable reconstitution per protocol.

Laboratory record checklist

Compound identity recorded in lab notebook (name, lot, preparation date)
Analytical identity cross-checked against published sequence or structure
Potency or concentration documented from analytical certificate when available
Purity or HPLC data filed when provided with research material
Appearance noted: intact lyophilized cake or uniform powder
Sterility / endotoxin report archived when available
Storage temperature applied immediately per published stability guidance