Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Dihexa
A hepatocyte growth factor mimetic studied in synaptogenesis and memory research.
- Half-life (approx.)
- ~hours (approx., oral bioavailable)
- Diluent
- Oral vehicle or BW for injectable research
- Common vials
- 5, 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Dihexa (PNB-0408) is a hepatocyte growth factor (HGF) mimetic studied for potent synaptogenesis in memory-impairment rodent models. It crosses the blood-brain barrier in preclinical work — an unusual property among cognitive research compounds. Orally bioavailable HGF mimetic — rare among CNS-active compounds in peptide-adjacent catalogs.
Structure & identity
Small molecule HGF mimetic (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
- Sequence / structure
- Small molecule HGF mimetic (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
Mechanism
HGF mimetic that potently facilitates synapse formation via c-Met receptor activation. c-Met activation drives dendritic spine formation in hippocampal culture models.
Studies & clinical programs
Scopolamine memory impairment rats
Published research models
- Peer-reviewed literature documents endpoints under Scopolamine memory impairment rats experimental designs.
Synapse density histology
Published research models
- Peer-reviewed literature documents endpoints under Synapse density histology experimental designs.
Research models in literature
- Scopolamine memory impairment rats
- Synapse density histology
Literature highlights
- HGF mimetic potentiates synapse formation via c-Met in scopolamine memory-impairment models.
- Oral bioavailability distinguishes dihexa from peptide neurotrophin approaches.
- Synaptic density histology used as primary mechanistic endpoint.
Combination research notes
Cognitive research compares dihexa with Semax and cerebrolysin-class approaches.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized / powder | Desiccated, room temperature or refrigerated per published stability data | Small-molecule powders are often hygroscopic or light-sensitive; store sealed with desiccant and record lot expiration on receipt. |
| Reconstituted / dissolved | Vehicle per formulation (aqueous, DMSO, or buffered solution) | Solution stability varies widely by solvent and pH; prepare fresh working stocks when literature reports rapid degradation. |
| Working aliquots | Frozen (−20 °C) or freshly prepared same-day | Aliquot in light-protected tubes when compounds are photolabile; avoid repeated thaw cycles on concentrated stocks. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Reconstituted per research protocol; oral and injectable forms differ.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance