Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
HGH
Recombinant growth hormone studied in GH-deficiency and body-composition research.
- Half-life (approx.)
- ~3–5 h (approx., subQ); IV shorter
- Diluent
- Published formulation diluent or bacteriostatic water
- Common vials
- 10, 24, 36 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Recombinant human growth hormone (somatropin) is a 191-amino-acid protein studied in GH-deficiency and body-composition research. Potency is labeled in IU (international units) — always verify IU/mg conversion on your research certificate. Recombinant somatropin — IU labeling standard across approved and research products.
Structure & identity
191-amino-acid somatropin (recombinant GH)
- Sequence / structure
- 191-amino-acid somatropin (recombinant GH)
Status: FDA-approved somatropin products; IU-labeled.
Mechanism
FDA-approved somatropin products; IU-labeled.
Binds GH receptor, stimulating IGF-1 production and direct lipolytic/growth effects. Direct GHR activation and hepatic IGF-1 production drive growth and lipolytic research endpoints.
Studies & clinical programs
GHD pediatric trials
Published research models
- Peer-reviewed literature documents endpoints under GHD pediatric trials experimental designs.
Adult GHD body composition studies
Published research models
- Peer-reviewed literature documents endpoints under Adult GHD body composition studies experimental designs.
Research models in literature
- GHD pediatric trials
- Adult GHD body composition studies
Literature highlights
- Recombinant somatropin evaluated in pediatric and adult GHD trials for growth and body composition.
- IGF-1 axis stimulation and direct lipolytic effects characterized in clamp studies.
- IU-based labeling standard in approved and research somatropin products.
Combination research notes
GH-axis research distinguishes exogenous hGH from secretagogue stacks (GHRH + GHRP blends).
Key targets & pathways
Research areas
Routes in research literature
Also known as
Handling cautions
- IU-based — never dose by mg alone
- Do not shake — swirl gently
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Refrigerated (2–8 °C); do not shake vial | Recombinant proteins and glycoproteins require gentle handling; inspect cake integrity and store upright per IU potency literature. |
| Reconstituted | Manufacturer diluent or bacteriostatic water, refrigerated | Swirl gently until dissolved — never shake vigorously; refrigerated stability is often shorter than small peptides (days to ~2 weeks). |
| Working aliquots | Frozen (−20 °C) in protein-grade tubes | Aliquot by IU or mg immediately after reconstitution; label concentration and avoid foam formation during draw. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 10 | 1 | 10000.0 | 1 | 2.5 | 5 |
| 24 | 1 | 24000.0 | 0.4 | 1 | 2.1 |
| 36 | 1 | 36000.0 | 0.3 | 0.7 | 1.4 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
IU-based; follow label IU/mg and sterile diluent instructions.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance