Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Sermorelin
A GHRH fragment studied in growth-hormone stimulation research.
- Half-life (approx.)
- ~6–12 min (approx., IV)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 2, 5 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Sermorelin acetate is the 1-29 amino-terminal fragment of GHRH, studied as a diagnostic probe and GH-stimulation agent in endocrine research. It was formerly used clinically for GH deficiency testing before being largely replaced by broader analogs. Short GHRH(1-29) fragment for GH stimulation testing — distinct from stabilized tesamorelin.
Structure & identity
GHRH(1-29) fragment — 29 amino acids
- Sequence / structure
- GHRH(1-29) fragment — 29 amino acids
Status: Formerly FDA-approved diagnostic; discontinued commercially in US.
Mechanism
Formerly FDA-approved diagnostic; discontinued commercially in US.
GHRH(1-29) fragment stimulates pituitary GH release for diagnostic and research stimulation. Diagnostic GH stimulation distinguishes pituitary reserve in endocrine research protocols.
Studies & clinical programs
GH stimulation diagnostic tests
Published research models
- Peer-reviewed literature documents endpoints under GH stimulation diagnostic tests experimental designs.
Pediatric GHD research
Published research models
- Peer-reviewed literature documents endpoints under Pediatric GHD research experimental designs.
Research models in literature
- GH stimulation diagnostic tests
- Pediatric GHD research
Literature highlights
- GHRH(1-29) fragment used in GH stimulation diagnostic tests and pediatric GHD research.
- Pituitary GH release curves compared with tesamorelin and CJC-class analogs.
- Formerly FDA-approved diagnostic — discontinued US commercial availability noted in literature.
Combination research notes
GH-axis research compares sermorelin with CJC no-DAC and ipamorelin combinations.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 2 | 2 | 1000.0 | 10 | 25 | 50 |
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with 1–2 mL bacteriostatic water.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance