Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
GHRP-6
A GH secretagogue peptide studied in endocrine and appetite research.
- Half-life (approx.)
- ~30 min (approx.)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 5, 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
GHRP-6 was among the first synthetic GH-releasing peptides, notable for strong ghrelin-mediated appetite effects in animal studies. It remains a reference compound in GH-axis pharmacology and receptor-characterization work. Potent GH secretagogue with pronounced ghrelin-mediated appetite stimulation in feeding studies.
Structure & identity
Hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys
- Sequence / structure
- Hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys
Mechanism
Potent GHS-R1a agonist with strong GH release and pronounced ghrelin-mediated appetite effects. Strongest appetite drive among common GHRPs — relevant when designing food-intake-controlled models.
Studies & clinical programs
GH secretion clamp studies
Published research models
- Peer-reviewed literature documents endpoints under GH secretion clamp studies experimental designs.
Food intake monitoring
Published research models
- Peer-reviewed literature documents endpoints under Food intake monitoring experimental designs.
Research models in literature
- GH secretion clamp studies
- Food intake monitoring
Literature highlights
- Potent GHS-R1a agonist with pronounced ghrelin-mediated appetite effects in rodent feeding studies.
- GH secretion clamp protocols use GHRP-6 as reference secretagogue.
- Among the strongest appetite-stimulating GHRPs in preclinical literature.
Combination research notes
Dual GH-axis research uses GHRP-6 with GHRH peptides; compare selectivity with ipamorelin.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with 1–2 mL bacteriostatic water.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance