Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Adipotide (FTTP)
A peptidomimetic studied in preclinical models of white adipose tissue targeting.
- Half-life (approx.)
- ~minutes (approx., rapid clearance)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 2, 5 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Adipotide (FTTP) is a peptidomimetic designed to target blood vessels supplying white adipose tissue in primate and rodent studies. Research examines selective adipose depots and metabolic markers — not intended for therapeutic use outside controlled studies. Prohibitin-targeted peptidomimetic studied primarily in primate adipose-depletion models.
Structure & identity
CKGGRAKDC-GG-D(KLAKLAK)2 peptidomimetic
- Sequence / structure
- CKGGRAKDC-GG-D(KLAKLAK)2 peptidomimetic
Status: Preclinical only — significant toxicity research in primate studies.
Mechanism
Preclinical only — significant toxicity research in primate studies.
Targets prohibitin on white-adipose vasculature, inducing apoptosis in adipose endothelium. Vascular apoptosis in white adipose depots is the proposed depot-selective mechanism.
Studies & clinical programs
Obese rhesus macaques
Published research models
- Peer-reviewed literature documents endpoints under Obese rhesus macaques experimental designs.
White adipose vasculature models
Published research models
- Peer-reviewed literature documents endpoints under White adipose vasculature models experimental designs.
Research models in literature
- Obese rhesus macaques
- White adipose vasculature models
Literature highlights
- Prohibitin-targeted peptidomimetic studied in obese rhesus macaque adipose-depletion models.
- White-adipose vascular apoptosis endpoints measured via imaging and metabolic panels.
- Primate safety literature documents renal and dehydration concerns — educational preclinical context only.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 2 | 2 | 1000.0 | 10 | 25 | 50 |
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with bacteriostatic water per protocol.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance