Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
5-Amino-1MQ
A small-molecule NNMT inhibitor studied in metabolic and adipose-tissue research models.
- Half-life (approx.)
- ~2–4 h (approx., oral rodent PK)
- Diluent
- DMSO or aqueous vehicle per formulation
- Common vials
- 50, 100 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor explored in rodent models of metabolic dysfunction. Research interest centers on NAD+ pathway modulation and adipose-tissue energy expenditure rather than classical peptide signaling. Listed in metabolic research catalogs as an NNMT inhibitor rather than a classical peptide agonist.
Structure & identity
Small molecule — 5-amino-1-methylquinolinium (NNMT inhibitor)
- Sequence / structure
- Small molecule — 5-amino-1-methylquinolinium (NNMT inhibitor)
Mechanism
Inhibits NNMT, raising cellular NAD+ and shifting methyl-nicotinamide metabolism in adipose models. Rodent studies report shifts in adipose NAD+ pools without direct receptor agonism.
Studies & clinical programs
Diet-induced obesity mice
Published research models
- Peer-reviewed literature documents endpoints under Diet-induced obesity mice experimental designs.
3T3-L1 adipocytes
Published research models
- Peer-reviewed literature documents endpoints under 3T3-L1 adipocytes experimental designs.
NNMT activity assays
Published research models
- Peer-reviewed literature documents endpoints under NNMT activity assays experimental designs.
Research models in literature
- Diet-induced obesity mice
- 3T3-L1 adipocytes
- NNMT activity assays
Literature highlights
- NNMT inhibition and NAD+ pathway flux studied in diet-induced obesity rodent models.
- Adipocyte and hepatocyte culture work examines methyl-nicotinamide metabolite shifts.
- Often positioned in metabolic research alongside NAD+ cofactor and precursor studies.
Combination research notes
Sometimes combined with NAD+ precursors in metabolic research.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Handling cautions
- Hygroscopic — keep desiccated
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized / powder | Desiccated, room temperature or refrigerated per published stability data | Small-molecule powders are often hygroscopic or light-sensitive; store sealed with desiccant and record lot expiration on receipt. |
| Reconstituted / dissolved | Vehicle per formulation (aqueous, DMSO, or buffered solution) | Solution stability varies widely by solvent and pH; prepare fresh working stocks when literature reports rapid degradation. |
| Working aliquots | Frozen (−20 °C) or freshly prepared same-day | Aliquot in light-protected tubes when compounds are photolabile; avoid repeated thaw cycles on concentrated stocks. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 50 | 2 | 25000.0 | 0.4 | 1 | 2 |
| 100 | 2 | 50000.0 | 0.2 | 0.5 | 1 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Often supplied as powder; reconstitution depends on formulation and solvent.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance