Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
AOD-9604
A fragment of human growth hormone studied in lipid-metabolism research.
- Half-life (approx.)
- ~30 min (approx.)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 2, 5 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
AOD-9604 is a modified C-terminal fragment of human growth hormone studied for lipolytic signaling without full GH receptor agonism. Rodent studies examine fat oxidation and body-composition endpoints under defined protocols. Tyrosine-modified hGH fragment variant commonly cross-listed with unmodified fragment 176-191.
Structure & identity
hGH fragment 176-191 with tyrosine modification (16 aa)
- Sequence / structure
- hGH fragment 176-191 with tyrosine modification (16 aa)
Mechanism
hGH fragment that stimulates lipolysis via β3-adrenergic pathways without IGF-1 elevation. Lipolytic signaling without IGF-1 axis engagement distinguishes it from full-length GH research.
Studies & clinical programs
Obese Zucker rats
Published research models
- Peer-reviewed literature documents endpoints under Obese Zucker rats experimental designs.
Lipolysis assays
Published research models
- Peer-reviewed literature documents endpoints under Lipolysis assays experimental designs.
Body composition DEXA
Published research models
- Peer-reviewed literature documents endpoints under Body composition DEXA experimental designs.
Research models in literature
- Obese Zucker rats
- Lipolysis assays
- Body composition DEXA
Literature highlights
- hGH fragment lipolysis studied in obese Zucker rats without IGF-1 elevation.
- β3-adrenergic pathway involvement examined in adipocyte culture systems.
- Body-composition endpoints compared with unmodified hGH fragment 176-191 in published literature.
Combination research notes
Frequently compared with hGH fragment 176-191 in published metabolic literature.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 2 | 2 | 1000.0 | 10 | 25 | 50 |
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with 1–2 mL bacteriostatic water.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance