Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
FOXO4-DRI
A D-retro-inverso peptide studied in senescent-cell clearance research models.
- Half-life (approx.)
- ~hours (approx., senolytic research)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
FOXO4-DRI is a D-retro-inverso peptide that disrupts FOXO4-p53 interaction to selectively induce apoptosis in senescent cells (senolytic research). Preclinical work in mice examines tissue rejuvenation markers after senescent-cell clearance. Senolytic D-retro-inverso peptide targeting FOXO4-p53 interaction in senescent cells.
Structure & identity
D-retro-inverso peptide FOXO4-DRI (senolytic)
- Sequence / structure
- D-retro-inverso peptide FOXO4-DRI (senolytic)
Status: Preclinical senolytic research stage.
Mechanism
Preclinical senolytic research stage.
D-retro-inverso peptide disrupts FOXO4-p53 interaction in senescent cells, triggering apoptosis. Selective apoptosis of senescent cells reduces SASP burden in progeroid mouse models.
Studies & clinical programs
Progeroid mice
Published research models
- Peer-reviewed literature documents endpoints under Progeroid mice experimental designs.
Senescent cell p16 assays
Published research models
- Peer-reviewed literature documents endpoints under Senescent cell p16 assays experimental designs.
Hair regrowth models
Published research models
- Peer-reviewed literature documents endpoints under Hair regrowth models experimental designs.
Research models in literature
- Progeroid mice
- Senescent cell p16 assays
- Hair regrowth models
Literature highlights
- D-retro-inverso peptide disrupts FOXO4-p53 in senescent-cell clearance models.
- Senolytic research examines p16+ cell burden and tissue rejuvenation markers.
- Progeroid and chemotherapy-induced senescence models used as preclinical contexts.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with bacteriostatic water per protocol.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance