Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Survodutide
A GLP-1/glucagon dual agonist studied in obesity and NASH research.
- Half-life (approx.)
- ~days (approx., subQ; phase trials)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 5, 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Survodutide (BI 456906) is a GLP-1/glucagon dual agonist in phase 2 trials for obesity and MASH (metabolic dysfunction-associated steatohepatitis). Glucagon component adds hepatic fat oxidation to GLP-1-mediated satiety in its research rationale. GLP-1/glucagon dual agonist (BI 456906) in phase 2 obesity and MASH research.
Structure & identity
GLP-1/glucagon dual agonist BI 456906
Status: Investigational.
Mechanism
Survodutide engages GLP-1 and glucagon receptors, combining appetite suppression with hepatic fat oxidation signals in published metabolic research.
GLP-1/glucagon dual agonist combining appetite suppression with hepatic fat oxidation. Glucagon component adds hepatic fat oxidation to GLP-1-mediated satiety signaling.
Studies & clinical programs
Phase 2 dual agonist trials(Phase 2)
Obesity and MASH research populations
- GLP-1 and glucagon dual agonism studied for weight and hepatic fat endpoints.
Research models in literature
- Phase 2 obesity trials
- MASH/NAFLD liver fat MRI studies
Literature highlights
- GLP-1/glucagon dual agonist (BI 456906) in phase 2 obesity and MASH/NAFLD liver-fat trials.
- Hepatic fat MRI and weight endpoints combined in metabolic liver-disease research.
- Investigational — compared with retatrutide and semaglutide in trial landscape reviews.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Reconstituted per research protocol.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance