Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Kisspeptin-10
A neuropeptide fragment studied in reproductive endocrine research.
- Half-life (approx.)
- ~4 min (approx., IV); short subQ
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 5, 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Kisspeptin-10 is the active fragment of the kisspeptin family that stimulates GnRH neurons, studied in reproductive-endocrine and IVF research. Human studies examine LH surge induction and hypothalamic-pituitary-gonadal axis activation. Upstream activator of GnRH neurons — initiates LH surge in reproductive endocrinology research.
Structure & identity
Decapeptide YNWNSFGLRF — KISS1 fragment
- Sequence / structure
- Decapeptide YNWNSFGLRF — KISS1 fragment
Mechanism
Stimulates GnRH neurons via KISS1R, initiating LH surge in reproductive research. KISS1R signaling on GnRH neurons is the gatekeeper for puberty and ovulation timing studies.
Studies & clinical programs
IVF LH surge induction
Published research models
- Peer-reviewed literature documents endpoints under IVF LH surge induction experimental designs.
Hypogonadotropic hypogonadism studies
Published research models
- Peer-reviewed literature documents endpoints under Hypogonadotropic hypogonadism studies experimental designs.
Research models in literature
- IVF LH surge induction
- Hypogonadotropic hypogonadism studies
Literature highlights
- KISS1R activation initiates GnRH neuron firing and LH surge in reproductive research.
- IVF and hypogonadotropic hypogonadism studies use kisspeptin as GnRH upstream probe.
- Very rapid clearance — IV bolus and infusion PK heavily featured in literature.
Combination research notes
IVF research examines kisspeptin-10 as alternative to GnRH agonist trigger protocols.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 5 | 2 | 2500.0 | 4 | 10 | 20 |
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Typically reconstituted with 1–2 mL bacteriostatic water.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance