Peptide
Reference library
Educational peptide reference — research use only.
Research & educational use only
For laboratory and educational research only. Not for human or veterinary consumption. This is not medical advice. Always follow applicable laws and consult qualified professionals.
The calculator performs unit math for research reference. It must not be used to plan or guide dosing in humans or animals. Verify all figures independently in your lab protocol.
Melanotan II (MT-2)
A melanocortin agonist studied in pigmentation and central receptor research.
- Half-life (approx.)
- ~50 min (approx.)
- Diluent
- Bacteriostatic water (0.9% benzyl alcohol)
- Common vials
- 10 mg
Half-life figures are literature approximations for educational reference — not pharmacokinetic advice.
Overview
Melanotan II is a potent non-selective melanocortin receptor agonist studied for pigmentation, sexual-function, and appetite endpoints. Its CNS penetration distinguishes it from MT-I in receptor-binding and side-effect research. Broad melanocortin agonist with central MC4R activity — distinct from MT-1 selectivity.
Structure & identity
Cyclic lactam α-MSH analog Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]
- Sequence / structure
- Cyclic lactam α-MSH analog Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]
Mechanism
Non-selective melanocortin agonist (MC1R/MC3R/MC4R/MC5R) with CNS penetration. CNS-penetrant melanocortin signaling affects pigmentation and central appetite/arousal circuits.
Studies & clinical programs
Melanin index measurement
Published research models
- Peer-reviewed literature documents endpoints under Melanin index measurement experimental designs.
Central MC4R behavioral studies
Published research models
- Peer-reviewed literature documents endpoints under Central MC4R behavioral studies experimental designs.
Research models in literature
- Melanin index measurement
- Central MC4R behavioral studies
Literature highlights
- Non-selective melanocortin agonist with CNS penetration in MC4R behavioral studies.
- Melanin index and central appetite/arousal endpoints in rodent models.
- Broader receptor profile than MT-1 — literature compares MC1R vs MC4R selectivity.
Combination research notes
Melanocortin research compares MT-2 with PT-141 (bremelanotide) MC4R selectivity.
Key targets & pathways
Research areas
Routes in research literature
Also known as
Stability & storage phases
| Phase | Condition | Guidance |
|---|---|---|
| Lyophilized | Sealed vial, refrigerated (2–8 °C) | Intact lyophilized cake or powder is typically stable for months to years per published stability data; protect from moisture, light, and repeated freeze-thaw of the dry vial. |
| Reconstituted | Bacteriostatic water (0.9% benzyl alcohol), refrigerated | Most aqueous peptide solutions remain usable for approximately 2–4 weeks refrigerated; verify published stability data and label with reconstitution date. |
| Working aliquots | Pre-drawn syringes or microtubes, frozen (−20 °C) | Aliquot promptly after mixing to limit freeze-thaw cycles on the main vial; thaw once and use to reduce protease-mediated degradation. |
Stability windows are formulation-dependent — verify published data and your lab SOP.
Reconstitution reference table
| Vial (mg) | Diluent (mL) | mcg/mL | Units @ 100 mcg | Units @ 250 mcg | Units @ 500 mcg |
|---|---|---|---|---|---|
| 10 | 2 | 5000.0 | 2 | 5 | 10 |
U-100 insulin syringe scale (100 units = 1 mL). Illustrative only — not dosing guidance.
Reconstitution steps
- Allow vial to reach room temperature (15–30 min)
- Swab rubber stopper with alcohol prep pad
- Draw calculated bacteriostatic water into syringe
- Inject diluent slowly down vial wall — do not spray directly onto cake
- Gently swirl until fully dissolved — do not shake vigorously
- Label with date, concentration, and diluent volume
- Refrigerate and use within your lab stability window
Reconstituted per research protocol; formulation varies by published formulation.
Laboratory record checklist
- Compound identity recorded in lab notebook (name, lot, preparation date)
- Analytical identity cross-checked against published sequence or structure
- Potency or concentration documented from analytical certificate when available
- Purity or HPLC data filed when provided with research material
- Appearance noted: intact lyophilized cake or uniform powder
- Sterility / endotoxin report archived when available
- Storage temperature applied immediately per published stability guidance